PriorCD: Prioritizing Cancer Drugs for Interested Cancer

Prioritize candidate cancer drugs for drug repositioning based on the random walk with restart algorithm in a drug-drug functional similarity network. 1) We firstly constructed a drug-drug functional similarity network by integrating pathway activity and drug activity derived from the NCI-60 cancer cell lines. 2) Secondly, we calculated drug repurposing score according to a set of approved therapeutic drugs of interested cancer based on the random walk with restart algorithm in the drug-drug functional similarity network. 3) Finally, the permutation test was used to calculate the statistical significance level for the drug repurposing score.

Version: 0.1.0
Depends: R (≥ 2.10)
Imports: igraph, dplyr, ROCR, visNetwork
Suggests: knitr, rmarkdown
Published: 2019-02-24
Author: Junwei Han [ctb, cre], Jieyi Di [aut], Baotong Zheng [aut]
Maintainer: Junwei Han <hanjunwei1981 at 163.com>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: no
CRAN checks: PriorCD results

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Reference manual: PriorCD.pdf
Vignettes: Vignette Title
Package source: PriorCD_0.1.0.tar.gz
Windows binaries: r-devel: PriorCD_0.1.0.zip, r-release: PriorCD_0.1.0.zip, r-oldrel: PriorCD_0.1.0.zip
OS X binaries: r-release: PriorCD_0.1.0.tgz, r-oldrel: PriorCD_0.1.0.tgz

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